Vitamin B-6-Induced Neuropathy: Exploring the Mechanisms of Pyridoxine Toxicity

Pyridoxine and the isoniazid-induced neuropathy.

Response of vitamin B-6 deficiency and the carpal tunnel syndrome to pyridoxine.

The specific activities and percentage deficiencies of the glutamic oxaloacetic transaminase of erythrocytes (EGOT) were determined for patients with carpal tunnel syndrome (CTS) diagnosed by clinical examination and electrical conduction data; the EGOT data revealed a severe deficiency of vitamin B-6. After double-blind treatment with pyridoxine and placebo, two physicians identified those rec...

The mechanisms of vitamin D toxicity.

Vitamin D intoxication is a hypercalcemic and hypercalciuric state which is suggestive of excess 1,25(OH) 2 D-like activity. Major aspects of vitamin D toxicity have been reviewed by Coburn and Barbour [1] and by Stern and Bell [2]. Among the factors that may predispose individuals to vitamin D intoxication are increased calcium intake, decreased renal function, diminished estrogen levels, the ...

Pyridoxine induced neuropathy by subcutaneous administration in dogs

To construct a sensory neuropathy model, excess pyridoxine (150 mg/kg s.i.d.) was injected subcutaneously in dogs over a period of 7 days. During the administrations period, the dogs experienced body weight reduction and proprioceptive loss involving the hindquarters. After pyridoxine administration was completed, electrophysiological recordings showed that the M wave remained at a normal state...

THE BIOLOGICAL ESTIMATION OF PYRIDOXINE (VITAMIN Be)*

Since the discovery of vitamin Bs, several biological assay procedures for this factor have been proposed (Gyorgy (1) ; Lunde and Kringstad (2); Wilson and Roy (3) ; Schneider et al. (4) ; Halliday and Evans (5) ; Edgar, El Sadr, and Macrae (6) ; Dimick and Schreffler (7); Reedman et al. (8)). These methods, with the exception of that of Edgar et al., are based upon the cure of acrodynia produc...